The invention discloses a molecular sieve desorber for an oxygen making system. The molecular sieve desorber comprises an air inlet pipe, a muffling container and an air outlet pipe, wherein the muffling container comprises more than four layers of muffling buckets which are embedded in sequence; the bucket mouths of two adjacent muffling buckets are in opposite directions; a gap is reserved between two adjacent muffling buckets to form an air flow channel; the muffling bucket on an innermost side is communicated with the air inlet pipe; the side wall of the muffling bucket on the innermost side is provided with a ventilation hole for communicating with the air flow channel; and the muffling bucket on an outermost side is communicated with the air outlet pipe. The molecular sieve desorberfor the oxygen making system, disclosed by the invention, has the advantages of simple structure, convenience and comfort for using, capabilities of effectively eliminating exhausting noise, reducingthe exhausting resistance, increasing the desorption capability and oxygen making efficiency of a molecular sieve, raising the performance standard of the oxygen making machine, and the like.