The invention relates to an application of hydrogen physiological saline in the preparation for a medicine treating acute cauda equine damage diseases. The invention further provides an application of a hydrogen-contained oral liquid in the preparation for a healthcare product treating acute cauda equine damage diseases. The advantages of the application of the invention are as follows: the new use of hydrogen physiological saline is developed, as well as an acute neurological damage protection function similar to that of methylprednisolone and a treatment effect to acute cauda equina syndrome of the hydrogen physiological saline are found; the hydrogen physiological saline is featured with simple preparation, high injection concentration, convenient use, no explosion risk, very low cost, no side effect and good treatment advantage, which greatly reduces the medicine side effect risk of the acute neurological damage patient and greatly decreases medical costs; the invention further develops a new use of the hydrogen-contained oral liquid, wherein the hydrogen-contained oral liquid is simply prepared, convenient for the patient to drink and with no toxic and side effects as well as great advantage to treat the acute cauda equina syndrome.