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CN102212178A 一种具备温度和pH双重敏感性的五嵌段共聚物、制备方法及其应用 失效 - 权利终止

一种具备温度和pH双重敏感性的五嵌段共聚物、制备方法及其应用
摘要：
本发明涉及一种具备温度和pH双重敏感性的五嵌段共聚物、制备方法及其应用。该方法主要步骤如下：对聚乙二醇表面改性，采用原子转移自由基聚合法（ATRP）来进行分子设计，使PEG两端逐步接上聚甲基丙烯酸-2-（二甲氨基）乙酯（PDMAEMA）和聚2-甲基-2-丙烯酸-2-（2-甲氧基乙氧基）乙酯（PMEO2MA）链段，制备了PMEO2MA-b-PDMAEMA-b-PEG-b-PDMAEMA-b-PMEO2MA五嵌段共聚物。本发明产物结构为线性，合成步骤简单，分子大小可控，具备温度和pH双重敏感性，可用于药物传递、基因载体、记忆元件开关的等多种智能材料领域。
摘要（英）：

The invention relates to a pentablock copolymer with temperature and pH dual sensitivity, and a preparation method and application thereof. The preparation method mainly comprises the following steps of: carrying out surface modification on poly(ethylene glycol) (PEG), and gradually grafting poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) and poly(2-(2- methoxyethoxy)ethyl 2-methyl-2-acrylate) (PMEO2MA) segments to two terminals of PEG by using an atom transfer radical polymerization (ATRP) method to carry out molecule design, thus preparing PMEO2MA-b-PDMAEMA-b-PEG-b-PDMAEMA-b-PMEO2MA pentablock copolymer. The pentablock copolymer provided by the invention has the characteristics of linear structure, simple synthesis process, controllable molecular size and dual sensitivity of temperature and pH, and can be used in multiple intelligent material fields of drug delivery, gene vector, memory elements and the like.

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