The invention belongs to the field of medicine, and relates to a preparation method of a Keke preparation, comprising the following steps of: respectively preparing ephedra and poppy capsule into ultrafine powder of 10-40mu m and ultrafine powder of 5-30mu m, and then mixing with the extracting solutions of other raw materials (licorice, bitter almond, radish seed, balloonflower and gypsum) of the Keke preparation except the ephedra and poppy capsule to prepare the Keke preparation. Compared with the traditional Keke preparations, the Keke preparation prepared by the scheme of the invention notably improves the asthma latent period of experimental asthmatic animals, the cough relieving effect is obviously better than that of the traditional Keke preparations, and the Keke preparation provided by the invention has an effect on treating emphysema, which is not possessed by the traditional Keke preparations.