The present invention, in one exemplary embodiment, relates a method of manufactupng an animal chew by molding two body portions of a first matepal each having at least one concave surface and one or more through holes, attaching the two portions together such that the concave surfaces face one another to form a hollow body portion, injecting a second matepal into the hollow body portion to fill at least a portion of the hollow body and form areas of exposed regions of the second matepal by filling the one or more through holes In a second exemplary embodiment, the two portions may have the concave surfaces over-molded with a second matepal which fills the holes In a third exemplary embodiment, a separate shape of a second matepal may be molded in a configuration having dimensions complementary to the two half portion and holes when the portions are combined