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发明授权
CN102178650B 一种前列地尔注射液及其制备方法 有权

一种前列地尔注射液及其制备方法
摘要：
本发明涉及一种前列地尔注射液及其制备方法，其处方组成如下：(a)主药前列地尔其浓度范围是5μg～15μg/ml；(b)油相为大豆油，其浓度范围分别为10.0～12.0％；(c)乳化剂选用大豆磷脂和泊洛沙姆188，其浓度范围分别为1.0～1.8％和0.02％～0.2％；(d)pH调节剂枸橼酸，其浓度范围是5mM至50mM，pH的范围是5.0至6.0；(d)渗透压调节剂甘油，其浓度范围分别为2.0～2.5％；其余为注射用水。
摘要（英）：

The invention relates to an alprostadil injection and a preparation method thereof. The alprostadil injection has a prescription as follows: a, a main drug is alprostadil with concentration of 5mu g-15mu g/ml; b, an oil phase is soybean oil with concentration of respectively 10.0-12.0 percent; c, soyabean lecithin and poloxamer 188 are selected as emulsifying agents and have concentrations of respectively 1.0-1.8 percent and 0.02-0.2 percent; d, citric acid is adopted as a pH regulating agent with concentration of 5nM to 50Mm and pH of 5.0-6.0; e, glycerol is adopted as an osmotic pressure regulating agent with concentration of respectively 2.0-2.5 percent; and f, the balance is injection water.

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