The invention discloses an electro luminescent bottle label and a waterproof manufacturing process thereof. The electro luminescent bottle label comprises an electro luminescent sign, an electro luminescent power supply lead strip and a battery box base, wherein the electro luminescent sign is connected with the battery box base through the electro luminescent power supply lead strip at the lowerend; a polyester (PET) film protection layer is adhered to a silk-screening layer; a waterproof layer is printed below a silver paste layer; a double-sided adhesive tape is adhered outside the waterproof layer; an upper cover of the battery box base and a lower cover of the battery box base are sealed together ultrasonically; a battery cover board is fixed on a central part of the lower cover of the battery box base by screws; a waterproof silica gel ring is arranged between the battery cover board and the battery box base; and a switch is a waterproof switch. The battery box base of the electro luminescent bottle label is designed to be fully matched with various bottle bottom structures, and the electro luminescent bottle label is manufactured by using the waterproof process, so the electro luminescent bottle label is elegant, waterproof, environment-friendly, and strong in applicability.