The invention relates to a high-efficiency air cleaner and belongs to the technical field of air purification. The high-efficiency air cleaner mainly comprises a water mist device, a fan and a gas-water separator, wherein the water mist device adopts a motor to drive a roller with small holes densely distributed on the surface; one third of the lower part of the roller is submerged in the water at the bottom part of a main body; as the small holes densely distributed on the surface of the roller capable of rotating at the high speed throw off the water, the uniform and fine water mist is formed in the main body; and the outside air is conveyed by the fan into the main body and then is discharged by the gas-water separator after the main body is cleaned by the water mist. The cleaner has asimple structure, is convenient to use and can efficiently eliminate the dust in the air and the harmful gas dissolved in the water after the air is washed, completely eliminate bacteria parasitic carriers and protect the health of people. The high-efficiency air cleaner is particularly suitable for hospitals, ward rooms, offices, families, machine rooms and other occasions.