The invention aims at providing a seismic isolation structure of a house, which can overcome the deficiencies in the prior art. A compound seismic isolation support saddle comprises a sliding seismic isolation layer and a superimposed seismic isolation layer, the two can play the seismic isolation role independently, after the two are used simultaneously, the seismic isolation safety stock is increased, and the safety is high; a floor plate in a rigid tray is prefabricated in a factory, thereby not only reducing field operation and being convenient to construct, but also overcoming the shortcoming that a lower template of the plate in the in-situ casting method is difficult to recover; in the construction, the construction is only basically performed on one layer of an original building, thereby causing few damages and few impacts to the original building, possibly realizing no class suspension or less class suspension during seismic strengthening in middle and primary schools and further solving the difficult problem of seismic strengthening in the middle and primary schools. For the ordinary houses, the advantages also exist and are very obvious.