The invention discloses an integrated biological invasion prevention optical cable and a preparation method thereof. The optical cable comprises a communication optical cable body. An outer sheath is arranged on the outermost layer of the communication optical cable body. An embossing stainless steel strip armor layer is additionally arranged outside the outer sheath. The preparation method of the optical cable comprises the following steps of preparing the communication optical cable body by steps of preparing a general optical cable, carrying out embossing processing on a stainless steel strip and then longitudinally coating the outer sheath of the optical cable; and carrying out continuous welding on an overlapping part of the stainless steel strip by using laser to form a corrugated stainless steel hose capable of being bent to protect the inside communication optical cable body. In the invention, the embossing stainless steel strip armor layer is additionally arranged outside the outer sheath of the communication optical cable and the characteristics of stainless steel material are utilized, wherein the rustproof characteristic solves the problem of long-term protection of the communication optical cable. Due to the hardness index of the integrated biological invasion prevention optical cable, all the biological invasions which are observed currently and generate damage to the optical cable can be completely prevented so as to fulfill the aim of compositively preventing the biological invasions.