The invention discloses ink-jet printing equipment with negative pressure, which is provided with a first cloth guiding roller, a first cloth pressing roller, a second cloth pressing roller and a second cloth guiding roller in sequence; an ink printing head and a negative pressure printing head are respectively vertically and oppositely arranged on a printing region arranged in the middle of the first cloth pressing roller and the second cloth pressing roller; the distance between the ink printing head and the negative pressure printing head is adjustable; and cloth is conveyed to the printing region through the first cloth guiding roller and the second cloth pressing roller, and the negative pressure printing head applies negative pressure at the reverse side of the cloth. During ink-jet printing, the negative pressure is applied to the reverse side of the cloth by aiming at an ink jetting head arranged on the front of the cloth, thus the infiltration velocity and the infiltration amount of ink in the vertical direction of the cloth are increased; and meanwhile, the infiltration velocity and the infiltration amount of ink in the horizontal direction of the cloth are reduced. The precision for design and color expression and the color fastness of the printing are improved.