The invention relates to a traditional Chinese medicine composition for treating acute and chronic osteomyelitis, which is prepared from the following raw medicines in proportioning by weight: 50-70g of salvia chinensis, 5-15g of sanguisorba, 5-15g of cogongrass rhizome, 1-5g of puberulous glochidion herb, 1-5g of cherokee rose, 5-15g of honeysuckle, 5-15g of dandelion, 0.05-0.15g of lilac daphne, 0.3-0.7g of wooly datchmanspipe herb, 0.5-1.5g of common cephalanoplos herb, 4-8g of licorice, 4-8g of tuckahoe, 4-8g of herba patriniae, 4-8g of radix scutellariae and 4-8g of phellodendron bark. Various raw medicines adopted in the invention are plant medicines with mild properties and are safe and reliable. The traditional Chinese medicine composition has the functions of clearing away heat and toxic material, promoting blood circulation, regulating qi, relieving pain, strengthening vital qi and eliminating toxicity, can be prepared simply and conveniently, and has the advantages of wide medicine sources, low cost and good treatment effect. Verified by 70 patients treated clinically, the effective rate is 96%, and the cure rate is 71%.