The invention provides an image sequence registration method, and belongs to the fields of a digital image processing technology and an OCR (optical character recognition) technology. The method comprises the following steps: step 1: calculating an integral image of images to be registered, wherein, the images to be registered comprise adjacent reference images and new images, and the adjacent reference images and new images are binarization images; step 2: zerofilling the images to be registered, and calculating related function values of the images to be registered after zerofilling throughan FFT (fast Fourier transform) algorithm; step 3: calculating registration coefficients point by point according to the integral image and related function values of the images to be registered; step 4: selecting candidate registration positions according to the registration coefficients; and step 5: obtaining registration results according to the related function values in the candidate registration positions. In the invention, by means of global search for the registration coefficients, the calculating accuracy of the registration positions is ensured; and by adopting an accelerated computing method, the rapidity of the calculation process is ensured.