The invention discloses a rail frame and a computer assembly fixing device with the same. The computer assembly fixing device comprises a frame body and a pair of rail frames, wherein the rail frames are used for being assembled at two sides of a computer assembly and arranged on the frame body, each rail frame is provided with a rail bar and a handle pivoted on the front end of the rail bar, thehandle is convenient for grabbing, and by pivoting the handle for an angle relative to the rail bar, the local part of the rail bar can be supported opposite to the direction of the computer assemblyto ensure that the rail bar and the frame body generate structural interference, thus the computer assembly is positioned in the frame body.