The invention discloses a manufacturing method of ceramic imitating the concavo-convex reticulation of sesame stone due to the furnace transmutation of a glaze layer in the firing process. The method comprises the steps of: preparing first glaze slurry containing tin dioxide, zirconium dioxide, nickel oxide and cobalt oxide, second glaze slurry containing cobalt oxide, nickel oxide, chromic oxide, ferric oxide and manganese dioxide, third glaze slurry containing tin dioxide, zirconium dioxide, nickel oxide and antimony oxide, and fourth glaze slurry containing diboron trioxide, calcium oxide,strontium oxide and zinc oxide; and orderly applying the first glaze slurry, the second glaze slurry, the third glaze slurry and the fourth glaze slurry on a ceramic body. After the firing, the glazelayer of the ceramic product has furnace transmutation and concavo-convex reticulations appear on the surface of the glaze layer; the concave parts are like scales in which color spots in grayish black and white and the like appear, and the depth and the distribution of the color spots are similar to the sesame stone and appearance visual effect of the sesame stone is provided; and the convex parts are white striped color spots among the scales and mutually connected to form reticulations.