The invention discloses a synthesis process of (2R)-(1,4-dioxane-2-yl)-N-methyl-methanamine hydrochloride. The synthesis process comprises the following steps: epoxy chloropropane and 2-chlorohydrin react to obtain (S)-3-(2-chlorooxethyl)-1-chloropropane-2-alcohol under the action of an salen catalyst; the (S)-3-(2-chlorooxethyl)-1-chloropropane-2-alcohol is subject to closed loop to obtain (2R)-2-[(2-chlorooxethyl) methyl]ethylene oxide under the action of carbonate; the (2R)-2-[(2-chlorooxethyl) methyl]ethylene oxide and hydroxide are subject to backflow reaction; toluenesulfonyl is added to the reaction product to obtain (2S)-1,4-dioxin-2-methyl-4-methyl p-toluenesulfonate ester; and the (2S)-1,4-dioxin-2-methyl-4-methyl p-toluenesulfonate ester and methylamine react in a high-pressure autoclave and hydrochloric acid is added to obtain the (2R)-(1,4-dioxane-2-methyl)-N-methyl-methanamine hydrochloride. In the synthesis process, a kinetic resolution technique is adopted so as to directly synthesize chiral compounds, raw materials can be obtained simply and easily, the reaction condition is mild, chiral separation is omitted, the cost is low and the synthesis process can be used for industrialized production.