The invention relates to a purification process for nevadensin, wherein the process flow comprises the following steps of: performing an ultrasonic extraction on the Lysionotus pauciflorus medical material serving as raw material by using alkaline water, performing membrane separation and concentration, performing fast absorption by a polyamide column, eluting with water and ethanol, concentrating and crystallizing the eluate, recrystallizing eluate in acetone and chloroform, and drying to obtain the final product. The process of producing nevadensin can reduce the amount of organic reagent, reduce energy consumption and reduce pollution. The method is suitable for industrialized promotion.