The invention provides a medicinal composition with anti-inflammatory and analgesic effects, which is prepared by taking extracts of lappaconitine hydrobromide and lamiophlomis rotate as raw materials. By performing a pharmacological research on the interaction and the compatibility formula of the extracts of the lappaconitine hydrobromide and the lamiophlomis rotate, results show that the medicinal composition of the invention can remarkably improve the pain threshold value of a mouse compared with the single use of the extract of the lappaconitine hydrobromide or the extract of the lamiophlomis rotate; and a mouse acetic writhing test, a mouse hot tub guy test, a rat paw swelling test caused by carrageenin and a mouse external ear swelling test caused by dimethylbenzene are performed byusing the medicinal composition of the invention, so that an optimum formula of the medicinal composition of the invention is obtained. The medicinal composition of the invention has remarkable anti-inflammatory and analgesic effects and wide application prospect.