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CN101932727A 通过极光激酶A的荧光原位杂交非侵入性检测膀胱癌 无效 - 驳回 复审申请

通过极光激酶A的荧光原位杂交非侵入性检测膀胱癌
摘要：
公开了检测患者中的膀胱癌的方法，其包括从患者的尿中分离膀胱细胞；使膀胱细胞与经标记的DNA探针杂交，其中探针识别极光激酶A基因的至少部分，以产生与经标记的DNA探针杂交的膀胱细胞样品；并且计数样品中的膀胱细胞数目、样品中的每个膀胱细胞中的极光激酶A基因拷贝数、和样品中具有极光激酶A基因的至少拷贝数第一阈值的膀胱细胞数目。
摘要（英）：

We disclose a method of detecting bladder cancer in a patient, comprising isolating bladder cells from the patient's urine; hybridizing the bladder cells with a labelled DNA probe, wherein the probe recognizes at least a portion of the aurora kinase A gene, to yield a sample of bladder cells hybridized with the labeled DNA probe; and counting the number of bladder cells in the sample, the number of copies of the aurora kinase A gene in each bladder cell in the sample, and the number of bladder cells in the sample having at least a first threshold number of copies of the aurora kinase A gene.

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