The invention relates to a reproducible desulfuration process special for a sintering machine and a starting method of a process system. The process method is characterized in that: sintering machine flue gas to be desulfurated is divided into at least two groups according to temperature; a group of to-be-desulfurated sintering machine flue gas with the highest temperature is subjected to dust removal and is conveyed to a reboiler; and a group of low-temperature sintering machine flue gas to be desulfurated is subjected to dust removal and is used as circulating gas to be conveyed to a gas inlet cover and the like of other groups. The starting method of the process system is characterized in that: a high-temperature gaseous medium provided by exterior is used as a heat source, the starting process is performed in two steps, and the like. The reproducible desulfuration process and the starting method have the main advantages that energy is saved, the treatment capacity of the to-be-desulfurated flue gas which is generated in the sintering machine can be reduced substantially on the basis of the prior art and the like, and are particularly suitable for the technical field of the desulfuration of a sintering machine system.