The invention discloses a medicine composition, which is prepared from raw medicine of gynostemma pentaphylla, hoantchy root, kudzu root, polygonatum, hawthorn and fenugreek through processing. Pharmacodynamic experiments show that the medicine composition of the invention has no influence on the body weight and fasting blood-glucose of mice, the fasting blood-glucose of low-tetraoxypyrimidine induced hyperglycemia model mice can be reduced, and the sugar tolerance of the model mice can be improved. In addition, clinical experiments prove that both the fasting blood-glucose and the blood-glucose after 2h of eating of patients eating the medicine composition of the invention are improved, the diabetes symptom and physical signs are obviously relieved or eliminated, the serum cholesterase and the triglyceride are obviously reduced, the high-density protein is obviously improved, and the fasting morning urine glucose integral value is obviously reduced. Thereby, the medicine composition of the invention has the obvious hyperglycemic effect.