The invention provides a vacuum pressure swing adsorption system, which comprises six adsorbers, two groups of independent blowers and three groups of independent vacuum pumps, wherein each group of blowers are connected with the inlet ends of four adsorbers respectively, each group of vacuum pumps are connected with the inlet ends of two adsorbers respectively, the inlet end of each adsorber is communicated with the atmosphere, the outlet ends of the two adsorbers connected with the each group of vacuum pumps are connected, and the outlet end of each adsorber is connected with a product gas tank. The vacuum pressure swing adsorption system cyclically executes the following steps of: adsorption, forward pressure release, vacuum desorption and pressure charge, wherein the ratio of the execution time of the adsorption step to the execution time of the vacuum desorption step is less than 1. The system can enlarge oxygen production scale, reduce the air quantity of the blowers, prolong the vacuum desorption time and reduce the pumping speed of the vacuum pumps so as to reduce energy consumption of the system and save the cost.