The invention provides a compound feed of pelteobagrus fulvidraco juvenile fish and a preparation method thereof. The compound feed comprises the following components in percentage by weight: 25-45% of fish meal, 4-8% of meat and bone meal, 15-20% of flour, 4-10% of corn, 10-20% of soy bean meal, 4-8% of rapeseed meal, 1-4% of fish oil, 10-20% of corn gluten meal, 1.0% of multivitamins, 1.0% of multiminerals, 0.1% of immunopotentiator, 0.2% of liver protecting agent, 0.2-0.4% of choline and 1-2% of calcium biphosphate. The compound feed has high quality grinding particle size, mixing uniformity, feed shaping property, water resistance and other characteristics. The pelteobagrus fulvidraco juvenile fish fed with the compound feed has body color close to the natural body color, and the compound feed can improve the anti-virus capability of the pelteobagrus fulvidraco juvenile fish, shorten the breeding cycle, reduce the breeding cost, reduce the sources of the diseases and water body pollution and has obvious economic and environmental benefits.