The invention relates to a bipolar plate frame and a galvanic pile of a flow battery, which belong to the field of flow batteries. The bipolar plate frame is characterized in that: labyrinth packing is formed by pressing two layers of O-shaped gasket rings which are arranged from inside to outside between an ion exchange membrane and the plate frame; an electrolyte channel and the O-shaped gasketrings are arranged on the region outside the two layers of the O-shaped gasket rings which are arranged from inside to outside; and an electrolyte groove is formed at the other side of an electrode frame opposite to the ion exchange membrane, and closely contacts the bipolar plate to form an electrolyte inlet channel or an electrolyte outlet channel. The bipolar plate frame and the galvanic pile of the flow battery have simple structures and completely solve the problem of cross leakage caused by loose sealing between anolyte and catholyte.