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发明公开
CN101790310A 溶瘤痘苗病毒癌症治疗 无效 - 驳回 转让 复审申请

溶瘤痘苗病毒癌症治疗
摘要：
本发明的实施方式涉及包括胸腺嘧啶激酶缺陷的痘苗病毒的方法。该方法包括以增加的病毒浓度给予痘苗病毒。本发明的另一些方面包括用于在荷瘤对象中诱导溶瘤或肿瘤血管崩解的方法，所述方法包括给予对象足以诱导肿瘤细胞溶瘤的至少1×108个TK-缺陷、表达GM-CSF、具有复制能力的痘苗病毒载体的病毒颗粒。
摘要（英）：

Embodiments of the invention are directed methods that include a thymidine kinase deficient vaccinia virus. The methods include administering the vaccinia virus at increased viral concentrations. Further aspects of the invention include methods for inducing oncolysis or collapse of tumor vasculature in a subject having a tumor comprising administering to a subject administered at least 1 x 108 viral particles of a TK-deficient, GM-CSF-expressing, replication-competent vaccinia virus vector sufficient to induce oncolysis of cells in the tumor.

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