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发明授权
CN101781372B 一种党参多糖的硫酸化修饰方法 失效 - 权利终止

一种党参多糖的硫酸化修饰方法
摘要：
本发明为一种党参多糖的硫酸化修饰方法，属于中药多糖的结构改造技术领域。提取、纯化党参多糖，用氯磺酸-吡啶法进行硫酸化修饰，以产物量和取代度为指标，用L9(34)正交实验对试剂配比、反应温度和反应时间3因素进行优选，确定最佳修饰条件为氯磺酸与吡啶的质量比1∶6、反应温度80℃、反应时间3h，所得硫酸化党参多糖的产物量和取代度高、活性强。本发明能显著提高党参多糖的抗病毒活性。
摘要（英）：

The invention relates to a sulphation modification method of codonopsis pilosula polysaccharide, belonging to the traditional Chinese medicine polysaccharide structure modification technical field. Codonopsis pilosula polysaccharide is extracted and purified, chlorosulfonic acid-pyridine method is used for carrying out sulphation modification, throughput and substitution ratio are taken as indexes, L9(34) orthogonal experiment method is used for optimization on three factors of reagent matching ratio, reaction temperature and reaction time, and the optimal modification conditions that mass ratio of chlorosulfonic acid and pyridine is 1:6, reaction temperature is 80 DEG C and reaction time is three hours are determined, and the obtained sulphated codonopsis pilosula polysaccharide is high in throughput and substitution ratio and strong in activity. The invention can obviously improve antiviral activity of codonopsis pilosula polysaccharide.

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