The invention relates to a quantitative self-destruct syringe which comprises a hollow needle cylinder, a push rod sliding in the needle cylinder and a rubber stopper mounted at the front end of the push rod, wherein a needle base is mounted at the front end of the needle cylinder, and the quantitative self-destruct syringe is characterized in that the needle base is provided with a support ring, an inner cavity for leading injection to pass through is arranged in the support ring, the support ring is in close fit with the conicity at the front end of the needle cylinder for keeping liquid sealing between the support ring and the needle cylinder, and the needle base is fixed with the front end of the needle cylinder by an elastic clamping and fixing structure. The adoption of the structure can clamp and fix the needle base with the needle cylinder by relying on a clamping pin on the support ring on the one hand, and lead the support ring to be in the close fit with the conicity of the needle cylinder on the other hand, thereby firmly fixing the needle base with the needle cylinder and keeping the liquid sealing between the two. A round table is arranged on the push rod, when a boss on the inner wall of the needle cylinder props against the round table of the push rod, the push rod can not be pulled back, thereby achieving the purpose of controlling the dose of pumped liquid.