The invention discloses a multifunctional plant composition which is characterized by comprising senecio plants, verbenaceae plants, solanum plants and serissa plants. Aiming at the limit of chemically synthesized antibiotic products, the invention provides a skin and mucosa antibiotic composition prepared from natural active matters, and the composition can effectively prevent and cure pathological changes of the skin and the mucosa of the human body, which is caused by bacteria or fungi. The invention has the advantages of environmental protection, no irritation, long-time and large-area use, strong antibiotic and antipruritic capacity, quick response, simple preparation process, low cost, and the like.