Disclosed are compositions comprising HFC-1225ye and other compounds that are useful as heat transfer fluids, including refrigerants, in a flooded evaporator chiller, a direct expansion chiller or a closed loop heat transfer system, such as a mobile air conditioning system. The compositions are also useful as cleaning solvents, aerosol propellants, foam blowing agents, fire extinguishing or suppression agents and sterilants. Also disclosed are methods for producing cooling and methods for replacing HFC-134a in a flooded evaporator chiller, a direct expansion chiller or a closed loop heat transfer system using such compositions.