The invention relates to a medicament for treating liver cancer, in particular to a medicament for treating liver cancer by combining traditional Chinese medicine and western medicine. The medicament is prepared from the following raw medicine materials: 20g of shark cartilage, 10g of basil polysaccharide, 10g of puerarin, 10g of vitamin C, 20g of pulvis corn, 20g of antelope horn powder, 20g of centipede, and 20g of American ginseng. A preparation method of the medicament adopts the following steps of: preparing the antelope horn powder, the centipede and the American ginseng and uniformly mixing; pulverizing by using an ultramicro pulverizer; sieving by a sieve of 100 meshes to obtain fine powder; uniformly mixing the fine powder and rest of raw medicine materials; and finally encapsulating. The preparation method has the characteristics of simple preparation process, small medicament loss and easy industrial production.