The invention relates to a molten-salt electrolytic aluminum inert anode, a preparation method and application thereof, which belongs to the technical field of metal-ceramic composite materials. The inert anode is synthesized through a metal phase and an oxide phase, wherein the oxide phase consists of Al2O3, ZrO2, V2O5, CeO2 and MgO micro-powder on a nanometer and quasi-nanometer scale, and the metal phase consists of Cu, Ni, Co, Fe, Al, Mn, Zn, Cr, Ti, Nb, V, Ta and Y powder on a micron scale. The method performs wet grinding, drying and isostatic/mechanical-pressure forming on nanometer and quasi-nanometer scale oxide powder and micron-scale mixed metal powder, and then performs sintering through a vacuum/protective-atmosphere sintering furnace and machining on the obtained product in order to obtain the inert anode. The inert anode is used as a substitute for molten-salt electrolytic aluminum carbon anodes. The inert anode has the advantages that the inert anode has good conductivity and high melting point; primary aluminum products produced by electrolysis is free from anode pollution; the inert anode is high in toughness, plasticity and hot strength, good in machining performance and low in cost; the impurity content of primary aluminum meets the requirements of national standards; and the amount of anode loss is up to 22 to 25 mm/year, and the like.