The invention relates to clothes and application thereof. The clothes mainly consist of sealing bags 1 and a pipeline coat 11, wherein the sealing bags 1 internally provided with ice cakes, water or heat reservoirs provide ice water or warm air for the pipeline coat 11 spreading from a collar (a hat or a pillow) to over shoulders, the front breast, the back, sleeves and lappets; by a method of exchanging positions of the two sealing bags 1, physical properties that water flows downwards, water and ice are cold, hot air can heat and heat dissipation can be achieved by blowing air are directly acted on a human body for temperature regulation, cold compress and thermal therapy. The clothes do not influence dressing habits, are comfortable, convenient, fashionable, beautiful, advanced and practical, save energy, reduce consumption and have no carbon emission, thus compared with air conditioners, electric fans, cotton-padded clothes, and the like, the clothes can regulate the temperature at all seasons. Particularly, when used indoors and outdoors in summer, the clothes can relieve summer heat, be used for enjoying the cool and have active and obvious health-care effect.