The invention relates to a medicament for treating prostate disease and a preparation process thereof, and belongs to the technical field of medicaments. The medicament is prepared from nineteen raw material medicaments such as giant knotweed rhizome, anemone clematis stem, eastern phellodendron, spreading hedyotis herb, shizandra, liquoric root and the like. The medicament has four different preparation processes, and one of the preparation processes comprises the following steps of: crushing raw material medicaments such as hairy antler, centipede, pangolin scales and earthworm into fine powder for later use; extracting the raw material medicaments such as the giant knotweed rhizome, the liquoric root, the anemone clematis stem, the eastern phellodendron, the spreading hedyotis herb and the shizandra with 30 to 80 percent ethanol; extracting raw material medicaments such as plantain seed, Indian buead, amassment, membranous milkvetch root, radish seed, cowherb seed, medlar, dodder and epimedium herb by decocting with water; then carrying out spray drying on an ethanol extract and decoction by a spray drying method; evenly mixing obtained dry extract powder and the fine powder of the hairy antler, the centipede, the pangolin scales and the earthworm; and tabletting the mixture to obtain the medicament. The medicament has the effects of clearing heat and disinhibiting dampness, promoting blood circulation and removing blood stasis, and nourishing kidney and freeing strangury, and has special effects of treating prostate damp-heat blood stasis diseases.