The invention relates to the technical field of extracts extracted from pomegranate rind and production methods and applications thereof, in particular to a pomegranate rind extract and a production method and application thereof. The pomegranate rind extract contains a flavone component and a tannin component. The pomegranate rind extract has obvious function of resisting influenza viruses, hepatitis B viruses and HIV viruses and can be used for preparing a broad-spectrum antiviral medicament. The invention proposes the function of the pomegranate rind extract in aspects of resisting the influenza viruses, the hepatitis B viruses and the HIV viruses for the first time; a macroporous resin adsorption and separation technology is applied for the first time in the production method of the pomegranate rind extract, the flavone component in the pomegranate rind is enriched from a crude extract of the pomegranate rind, and the extract with the total flavone content of 30 to 70 percent by weight, which contains 10-30 percent by weight of tannin, is obtained. The method is simple and easy, has reliable process and is suitable for industrialized production.