The invention discloses a setting method of a subscriber access control reason and a family base station gateway. The method comprises the following step: the family base station gateway sets corresponding rejection reasons according to international mobile subscriber identification codes and base station identifications, and/or type approval codes/location area codes, and/or matching conditions of seal group identifications. By the technical scheme, a family base station can adopt different processing according to the rejection reasons, thereby effectively preventing an unintended user form using wireless access service provided by a family cell.