The invention is a chemical soluble glass slurry for reinforcing and preventing leakage. The chemical slurry uses ethylene glycol monoethyl ether acetate as curing agent and soluble glass as main component. Based on 100 parts of slurry, the volume ratio of each component is as follows: 15-70 parts of soluble glass, 2.5-14 parts of ethylene glycol monoethyl ether acetate and water for the rest. The grouting material has the characteristics of large dispersion range, good penetration, adjustable curing time, simple operation, and the like. The slurry gel is nontoxic and has relatively higher pressure resistance. The invention can be widely used for preventing leakage in dam foundation, and has broad application prospect in water blocking and reinforcing project.