The embodiment of the invention discloses selection method and device of a modulation encoding mode, wherein the method comprises the following steps: selecting object primary transmission block error rate (IBLER) from a layer-two system level according to the combined gain of a hybrid automatic retransmission request (HARQ); obtaining an SINR adjusted quantity by a signal-to-interference and noise ratio (SINR) correction algorithm according to the object IBLER; utilizing the SINR adjusted quantity to adjust the original SINR to obtain a modified SINR; and selecting a modulation code combination MCS corresponding to an SINR operation interval into which the modified SINR falls. The spectrum effectiveness for receiving a signal can be improved according to the embodiment of the invention.