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发明授权
CN101638429B 一种特异性识别细胞表面整合素α3β1的小分子肽 失效 - 权利终止

一种特异性识别细胞表面整合素α3β1的小分子肽
摘要：
本发明提供了一种特异性识别细胞表面整合素α3β1的小分子肽，该小分子肽的氨基酸序列为cdGLGHypNc；其中，c表示D型半胱氨酸，d表示D型天冬氨酸，G表示L型甘氨酸，L表示L型亮氨酸，Hyp表示L型4-羟脯氨酸，N表示L型天冬酰胺。本发明所述小分子肽可通过常规的固相合成法合成得到，能特异性识别细胞表面整合素α3β1，因此可作为影像造影剂如荧光素的靶向载体，将荧光素运输到高表达α3β1的癌细胞表面，通过荧光素扫描仪器，实现肿瘤的分子影像诊断。
摘要（英）：

The invention provides a small molecular peptide of specificity recognition cell surface integrin alphal3beta1; the amino acid sequence of the small molecular peptide is cdGLGHypNc, wherein c expresses D type aminothiopropionic acid, d expresses D type aspartic acid, G expresses L type glycocoll, L expresses L type leucine, Hyp expresses L type 4-hydroxyproline, and N expresses L type aspartic acid. The small molecular peptide is obtained by the conventional solid-state reaction method, can specifically recognize the cell surface integrin alphal3beta1; therefore, the small molecular peptide can be used as image contrast agent such as a targeting carrier of the luciferin, transports the luciferin to the cancer cell surface of the high express alphal3beta1, realizes the molecule image diagnosis of tumor by a luciferin scanning device.

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