The application relates to dynamic headroom control for LED driver. An LED driver controller comprises a voltage regulator for controlling an output voltage to a top of a plurality of LED strings responsive to at least a reference voltage. A plurality of first circuitries each associated with a node at a bottom of each of the plurality of LED strings compares a voltage at the bottom of each of the plurality of LED strings with a high reference voltage and a low reference voltage. Control logic generates a first control signal when the voltage at the bottom of each node of the plurality of LED strings exceeds the high reference voltage and generates a second control signal when the voltage at least one of node of the plurality of LED strings falls below the low reference voltage. Second circuitry responsive to the first control signal and the second control signal generates the reference voltage. The reference voltage is controlled to cause the voltage at the bottom of the lowest voltage node of the plurality of LED strings to remain between the high reference voltage and the low reference voltage.