The invention discloses a light guide module, which is used for guiding light for luminous elements arranged on a luminous module. The light guide module comprises a retainer which is arranged on the luminous module and a plurality of light guide units which are arranged on the retainer corresponding to the luminous elements one by one; the retainer comprises a bottom plate which is attached to the luminous module and two lateral plates which are extended upwards from two side edges of the bottom plate; the insides of the lateral plates are provided with two opposite sliding chutes; two sidesof the light guide units are extended outwards and provided with combined edges; and the two combined edges are inserted from openings at the ends of the two sliding chutes of the lateral plates at the same time respectively so as to fix the light guide units into the retainer. The light guide units which are independently designed can be conveniently mounted and fixed to a light-emitting diode module as the luminous module through the retainer, so the independent light guide units can form various light guide modules, and the light guide modules are applicable to the luminous modules of different lamps.