The invention discloses a processing center and a presetting cutter method thereof. The processing center comprises a control system and a stand, wherein stand is provided with a vertical elevating axis, and a lead screw cap is arranged on the vertical elevating axis; at least two electric spindles used for processing elements are arranged on the stand, a vertical slide plate which enables the electric spindles only to move up and down is arranged on the lead screw cap, each electric spindle supports against the vertical slide plate and can move along the vertical slide plate, and a height regulating device used for regulating the height of a cutter is arranged on the vertical slide plate which is arranged on the top of the electric spindles; a locking device used for fixing the electric spindles is arranged on the vertical slide plate; a short-circuited circuit used for sending high blocks such as short circuit signals, electric connection and the like is arranged on the control system; and cutter presetting is completed by utilizing the relative mechanisms. In the invention, at least two electric spindles are arranged on the processing center, and the relative mechanisms are arranged on the electric spindles, thereby the accuracy of the processing center and the work efficiency of the processing center are at least doubled.