The invention belongs to the field of traditional Chinese medicine health-care products, in particular a traditional Chinese medicine health-care and nutritious wine which is prepared by soaking the following materials by weight part with 1500-5000 parts of wine at normal temperature: 25-75 parts of wolfberry fruit, 25-75 parts of chaff flower root, 45-80 parts of dogwood, 50-75 parts of radix rehmanniae, 30-75 parts of Eucommia ulmoides, 50-75 parts of chrysanthemum, 30-72 parts of radix paeoniae alba, 90-135 parts of cortex periplocae, 100-150 parts of parasitic loranthus, 200-260 parts of longan pulp, 20-40 parts of pawpaw, 24-40 parts of Angelica sinensis and 4.5-15 parts of cassia twig. The invention is simple to produce and convenient to eat, has good mouth feel, high nutrition value and obvious pesticide effect and has favorable health-care function to human bodies.