The invention discloses a photochromic thiazole hexatomic ring series-parallel asymmetric perfluoro-cyclopentene compound and a preparation method and application thereof. The photochromic material can keep good photochromic performance in solution or a film, has superior performances of good chemical and thermal stability, remarkable fatigue resistance, high cyclization quantum yield, good sensitivity and the like in an open-loop state (colorless state) and a closed-loop state (coloration state), and has an appointed absorption wavelength, wherein the absorption spectrum in the coloration state is between 400 and 600 nanometers which is just matched with a laser of which the wavelength is 532 nanometers. The photochromic material can be applied to developing an organic photochromic photon type recording medium with short wavelength and can also be applied to a switch for fluorescence detection and fluorescence light control; besides, the photochromic material is preliminarily appliedto high-density holographic optical storage, and the storage attribute is erasable photon type storage.