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发明授权
CN101591655B 一种特异性阻断PKCα信号传递的siRNA及其应用 失效 - 权利终止

一种特异性阻断PKCα信号传递的siRNA及其应用
摘要：
本发明公开了一种特异性阻断PKCα信号传递的siRNA，所述siRNA为以下针对人PKCα的双链RNA分子中的任意一种：正义链：5′-CGACGACUGUCUGUAGAAA-3′，反义链：5′-UUUCUACAGACAGUCGUCG-3′；正义链：5′-GGAUGGUACAAGUUGCUUA-3′，反义链：5′-UAAGCAACUUGUACCAUCC-3′；或正义链：5′-GGCGUCCUGUUGUAUGAAA-3′，反义链：5′-UUUCAUACAACAGGACGCC-3′；或所述siRNA为以下针对小鼠PKCα的双链RNA分子中的任意一种：正义链：5′-GAAUGAGAGCAAACAGAAA-3′，反义链：5′-UUUCUGUUUGCUCUCAUUC-3′；正义链：5′-GCAAAGGACUUAUGACCAA-3′，反义链：5′-UUGGUCAUAAGUCCUUUGC-3′；或正义链：5′-GCCCAAAGUGUGUGGCAAA-3′，反义链：5′-UUUGCCACACACUUUGGGC-3′，siRNA-PKCα特异性针对PKCα亚型，为治疗这类严重的致盲性眼病提供了一种新的药物特异性干预靶点的基因药物。
摘要（英）：

The invention discloses a PKCalpha signal specifically-blocking siRNA, which is one arbitrarily selected from the following double-stranded RNA molecules targeted at human PKCalpha: a sense strand of 5'-CGACGACUGUCUGUAGAAA-3' and an antisense strand of 5'-UUUCUACAGACAGUCGUCG-3', a sense strand of 5'-GGAUGGUACAAGUUGCUUA-3' and an antisense strand of 5'-GGCGUCCUGUUGUAUGAAA-3' or a sense strand of5'-GGCGUCCUGUUGUAUGAAA-3' and an antisense strand of 5'-UUUCAUACAACAGGACGCC-3'; or one arbitrarily selected from the following double-stranded RNA molecules targeted at mouse PKCalpha: a sense strand of5'-GAAUGAGAGCAAACAGAAA-3' and an antisense strand of 5'-UUUCUGUUUGCUCUCAUUC-3', a sense strand of 5'-GCAAAGGACUUAUGACCAA-3' and an antisense strand of 5'-UUGGUCAUAAGUCCUUUGC-3', or a sense strand of 5'-GCCCAAAGUGUGUGGCAAA-3' and an antisense strand of 5'-UUUGCCACACACUUUGGGC-3'. The siRNA-PKCalpha is specifically targeted at hypotype PKCalpha and provides a novel pharmaceutical specific intervention targeting gene medicament for treating blinding eye diseases of the same type.

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