The invention relates to a processing method of sludge containing oil and methanol in natural gas conditioning plants, comprising concentration treatment, centrifugal dehydration and incineration treatment, in particular comprising the following steps: the sludge is collected a the sludge concentration tank, dehydrating agent is added into an agent-feeding device which is arranged on the upper part the sludge concentration tank, simultaneously, two mixing devices are arranged on the upper part of the sludge concentration tank, thus being convenient for stirring the sludge so that the medicinecan come into full play; the sludge after dehydration is transported into a centrifugal dehydrator or a screw sludge extruding-desiccation machine through a screw sludge pump, and the sludge after centrifugal dehydration is transported to a rotary incinerator for incineration, and the residues after incineration are used for repairing roads or embedded into the appointed solid waste landfill sites. All the steps of the method are continuous and are interacted into a whole body; the method further has the advantages of simple processing flow, convenience and promptness, is applicable to processing the sludge containing oil and methanol in the natural gas conditioning plant and has great application value and good promotion prospect.