The invention discloses a method for smooth blasting construction, and in particular relates to a method for smooth blasting construction with pre-eccentric uncoupling charging. The invention aims to provide the method for the smooth blasting construction with pre-eccentric uncoupling charging, which can improve the side slope smooth blasting effect. The technical proposal comprises that the method for the smooth blasting construction with pre-eccentric uncoupling charging comprises the following steps: (1) drilling a hole according to design requirement, cleaning up sundries in the hole and beside the hole after drilling the hole to prevent the blasting hole from being blocked by the sundries; (2) processing an ammunition string: processing the ammunition string outside the hole according to the design, wherein the size ratio of the diameter of the charging hole to the diameter of the ammunition string or the uncoupling coefficient is between 3.0 and 4.0; (3) mounting well-processed brackets on the ammunition string at intervals according to construction requirements; (4) putting the ammunition string into the blasting hole slowly by pressing close to the upper hole wall, namely one side of a light blasting body and blocking the blasting hole; and (5) initiating the blasting. The method is mainly applicable for engineering blasting.