The invention discloses an equalization device and an equalization method in a cluster channel. A plurality of equalizers are arranged on the equalization device to eliminate multi-path interference caused by a plurality of clusters in a transmission channel, weights used in a plurality of the equalizers give different weights based on transmission gains of delay paths of various clusters in the whole transmission channel under the criterion of minimum mean square error, received delayed signals are equalized based on the different weights to obtain equalized signals, and then the equalized signals are combined to output combined signals. The equalization device and the equalization method can reduce the interference caused by the delay paths of the different clusters in the whole channel and improve efficiency of the equalizers.