The invention provides an ibuprofen (IBU) percutaneous-release paster and a preparation method thereof, belonging to the technical field of medicine. No ibuprofen percutaneous-release paster is available in the prior art. The paster of the invention comprises an anti-sticking layer, a drug-storing layer and a backing layer, wherein, the drug-storing layer comprises the following components: 5wt% to 15wt% of IBU, 28.5wt% to 65wt% of SIS, 25wt% to 54% of tackifying resin, 1wt% to 5wt% of compound penetration enhancer and 1wt% to 2wt% of compound anti-oxidant. The preparation method of the IBU percutaneous-release paster comprises the following steps: adding the other components after the SIS and the tackifying terpine resin swell in the organic solvent; agitating on an ultrasound basis; coating the anti-sticking layer; air drying and vacuum drying; and covering the backing layer. The percutaneous-release paster has the advantages that the paster is not irritant or allergic to skins, the drug release can be easily controlled and the duration of the drug effect is long.