The invention relates to a digital flexible assembly frame device, which consists of a frame framework and 16 mobile shape adjusting units, wherein the frame framework is formed by assembling an upper beam component, a lower beam component and an upright post component; a guide rail, a slider and a rack are arranged on the frame framework; the number of the mobile shape adjusting units is 16, wherein 8 mobile shape adjusting units are arranged on the upper beam component, and 8 mobile shape adjusting units are arranged on the lower beam component; the mobile shape adjusting units on the lowerbeam component and the mobile shape adjusting units on the upper beam component are symmetrically arranged; and each mobile shape adjusting unit is connected with a pair of sliders in a mode of screwed joint and comprises a mobile bracket, a motor, a speed reducer, a coupler, a lead screw, an angular contact bearing, a copper sleeve, a guide rod sleeve and other parts. The mobile shape adjusting units are core components of the digital flexible assembly frame device, and free shape adjustment in two directions of assembly points is realized by the mobile shape adjusting units. The digital flexible assembly frame device has the advantages of quick shape adjustment, high precision, good openness, strong universality and simple and reliable structure, and realizes assembly of various wall board parts with one frame in aircraft assembly.