The invention relates to a panel drive device, a method thereof and a liquid crystal display. The panel drive device comprises a time sequence controller, a gamma voltage generation unit and a source cathode driver, wherein the time sequence controller at least provides one data signal, the gamma voltage generation unit at least provides two gamma reference voltages, the source cathode driver is coupled with the time sequence controller and the gamma voltage generation unit and is controlled by the time sequence controller for receiving the data signal and the two gamma reference voltages and projecting two drive signals from the two gamma reference voltages according to the data signal to drive at least one pixel of a panel. The invention mixes the color of higher gray scale and the color of lower gray scale into a color of intermediate gray scale, therefore, users can watch the image of adjacent color tones, when users watch the image displayed on a liquid crystal display via front view or inclined view.